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Duocarmycin Analogues without a DNA‐Binding Indole Unit Associate with Aldehyde Dehydrogenase 1A1 and not DNA: A Reply
Author(s) -
Tietze Lutz F.,
Sieber Stephan A.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301923
Subject(s) - indole test , dna , aldehyde dehydrogenase , chemistry , stereochemistry , aldehyde , biochemistry , combinatorial chemistry , microbiology and biotechnology , biology , enzyme , catalysis
An open question : Activity‐based protein profiling using seco‐CBI derivative 1 , containing a DNA‐binding indole unit, showed that besides binding to DNA, compound 1 also interacts with aldehyde dehydrogenase 1. However, for CBI compounds without an indole unit, the origin of their cytotoxicity has not been identified, yet.