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Regioselectively Functionalized Pyridines from Sustainable Resources
Author(s) -
Michlik Stefan,
Kempe Rhett
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301919
Subject(s) - construct (python library) , pyridine , variety (cybernetics) , alcohol , computer science , service (business) , combinatorial chemistry , chemistry , condensation , organic chemistry , business , programming language , artificial intelligence , thermodynamics , physics , marketing
Make the most of it! An Ir‐catalyzed dehydrogenative condensation of alcohols and 1,3‐amino alcohol was used to construct pyridine derivatives regioselectively. This method provides access to unsymmetrically substituted pyridines and tolerates a wide variety of functional groups. Three equivalents of H 2 are generated per pyridine unit formed and the alcohol substrates become completely deoxygenated.