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Cinchona Alkaloid Amide/Copper(II) Catalyzed Diastereo‐ and Enantioselective Vinylogous Mannich Reaction of Ketimines with Siloxyfurans
Author(s) -
Hayashi Masashi,
Sano Masahide,
Funahashi Yasuhiro,
Nakamura Shuichi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301917
Subject(s) - cinchona , enantioselective synthesis , amide , mannich reaction , organic chemistry , catalysis , chemistry , alkaloid , combinatorial chemistry
Managing the Mannich : The first enantioselective vinylogous Mannich reaction of siloxyfurans with ketimines derived from unactivated ketones has been developed. Excellent yields and enantioselectivities were obtained using a new class of readily accessible cinchona alkaloid amide/Cu(OAc) 2 catalysts on a range of substrates.
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