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Noncovalent Interactions in Organocatalysis: Modulating Conformational Diversity and Reactivity in the MacMillan Catalyst
Author(s) -
Holland Mareike C.,
Paul Shyeni,
Schweizer W. Bernd,
Bergander Klaus,
MückLichtenfeld Christian,
Lakhdar Sami,
Mayr Herbert,
Gilmour Ryan
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301864
Subject(s) - reactivity (psychology) , catalysis , non covalent interactions , organocatalysis , chemistry , diversity (politics) , posttranslational modification , stereochemistry , molecule , biochemistry , organic chemistry , political science , hydrogen bond , enzyme , medicine , alternative medicine , pathology , enantioselective synthesis , law
Intriguing imidazolidinones! Inspired by noncovalent interactions in proteins, a series of electronically distinct MacMillan catalysts were designed. The effect of electronic modulation on ground state conformation, reactivity, and performance was studied in a catalytic setting with intriguing outcomes.