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Enantioselective Construction of α‐Quaternary Cyclobutanones by Catalytic Asymmetric Allylic Alkylation
Author(s) -
Reeves Corey M.,
Eidamshaus Christian,
Kim Jimin,
Stoltz Brian M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301815
Subject(s) - enantioselective synthesis , tsuji–trost reaction , catalysis , chemistry , alkylation , computer science , combinatorial chemistry , organic chemistry
No strain, no gain! The first transition metal‐catalyzed enantioselective α‐alkylation of cyclobutanones is reported. This method employs palladium catalysis and an electron‐deficient PHOX‐type ligand to afford all‐carbon α‐quaternary cyclobutanones in good to excellent yields and enantioselectivities (see scheme).