Premium
Highly Enantioselective Reduction of α‐Methylated Nitroalkenes
Author(s) -
Burda Edyta,
Reß Tina,
Winkler Till,
Giese Carolin,
Kostrov Xenia,
Huber Tobias,
Hummel Werner,
Gröger Harald
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301814
Subject(s) - enantioselective synthesis , computer science , enantiomer , reduction (mathematics) , chemistry , combinatorial chemistry , information retrieval , organic chemistry , mathematics , catalysis , geometry
Highly selective: The reduction of α‐methyl‐substituted nitroalkenes succeeds in a highly enantioselective fashion with an ene reductase from Gluconobacter oxydans. Under optimized reaction conditions the desired nitroalkanes are formed with enantiomeric excesses of up to 95% in these biotransformations.