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The Fatty Acid Composition of Diacylglycerols Determines Local Signaling Patterns
Author(s) -
Nadler André,
Reither Gregor,
Feng Suihan,
Stein Frank,
Reither Sabine,
Müller Rainer,
Schultz Carsten
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301716
Subject(s) - diacylglycerol kinase , composition (language) , signal (programming language) , computer science , fatty acid , biochemistry , service (business) , chemistry , signal transduction , computational biology , biology , protein kinase c , business , programming language , linguistics , philosophy , marketing
Caged compounds are designed to release biologically active signaling molecules with temporal, spatial, and even subcellular resolution. But how localized does the signal stay? Using the example of diacylglycerol, some signal responses (PKC) are shown to remain spatially distinct while other signals ([Ca 2+ ] i ) spread across the entire cell. Surprisingly, this distribution patterns depend on the fatty acid composition of the lipid species.