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Unusual Acetylation–Elimination in the Formation of Tetronate Antibiotics
Author(s) -
Kanchanabanca Chompoonik,
Tao Weixin,
Hong Hui,
Liu Yajing,
Hahn Frank,
Samborskyy Markiyan,
Deng Zixin,
Sun Yuhui,
Leadlay Peter F.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301680
Subject(s) - computer science , acetyltransferase , identity (music) , information retrieval , acetylation , biosynthesis , service (business) , world wide web , enzyme , chemistry , biochemistry , gene , philosophy , aesthetics , economy , economics
The identity and reactivity of the intermediates in agglomerin biosynthesis were established and the respective roles of the acetyltransferase Agg4 and the eliminating enzyme Agg5 identified (see scheme). It is proposed that enzymes homologous to Agg4 and Agg5 carry out the dehydration steps in all spirotetronate biosynthetic pathways. If this proves correct, it may assist engineering of these pathways.