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Nanosolvation‐Induced Stabilization of a Protonated Peptide Dimer Isolated in the Gas Phase
Author(s) -
Milosavljević Aleksandar R.,
Cerovski Viktor Z.,
Ca Francis,
Nahon Laurent,
Giuliani Alexandre
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301667
Subject(s) - dimer , protonation , gas phase , peptide , phase (matter) , d dimer , chemistry , organic chemistry , biochemistry , medicine , ion
A dash of water : Nanosolvation of a leucine–enkephalin peptide dimer by only three water molecules has a dramatic impact on its stability to VUV photon irradiation. A drastic reduction of the fragmentation abundance of the hydrated protonated peptide dimer precursor, isolated in the gas phase, was observed. Calculations show that hydration in fact stabilizes the dimer structure.