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The Winding Pathway to Erythropoietin Along the Chemistry–Biology Frontier: A Success At Last
Author(s) -
Wilson Rebecca M.,
Dong Suwei,
Wang Ping,
Danishefsky Samuel J.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301666
Subject(s) - chitobiose , erythropoietin , glycosylation , chemistry , glycan , biochemistry , homogeneous , computational biology , biology , glycoprotein , endocrinology , mathematics , chitin , combinatorics , chitosan
The total synthesis of a homogeneous erythropoietin (EPO), possessing the native amino acid sequence and chitobiose glycans at each of the three wild‐type sites of N glycosylation, has been accomplished in our laboratory. We provide herein an account of our decade‐long research effort en route to this formidable target compound. The optimization of the synergy of the two bedrock sciences we now call biology and chemistry was central to the success of the synthesis of EPO.