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Ruthenium‐Catalyzed Carbonylative CC Coupling in Water by Directed CH Bond Activation
Author(s) -
Tlili Anis,
Schranck Johannes,
Pospech Jola,
Neumann Helfried,
Beller Matthias
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301663
Subject(s) - ruthenium , catalysis , aryl , iodide , chemistry , carbonylation , combinatorial chemistry , medicinal chemistry , organic chemistry , carbon monoxide , alkyl
First things first : The title reaction of arenes bearing ortho‐ directing groups (DG) in the presence of a ruthenium catalyst and aryl iodide is presented. The reaction is general for variously substituted aryl iodides to give ketones in moderate to good yields, and water serves as the solvent. The system is highly selective towards the mono‐carbonylative arylation by ortho CH functionalization. cod=cyclo‐1,5‐octadiene.