Premium
Enantiomeric Selection Properties of β‐homoDNA: Enhanced Pairing for Heterochiral Complexes
Author(s) -
D'Alonzo Daniele,
Amato Jussara,
Schepers Guy,
Froeyen Matheus,
Van Aerschot Arthur,
Herdewijn Piet,
Guaragna Annalisa
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301659
Subject(s) - chirality (physics) , pairing , nucleic acid , chemistry , enantiomer , selection (genetic algorithm) , computer science , information retrieval , computational biology , stereochemistry , physics , biochemistry , biology , artificial intelligence , chiral symmetry breaking , superconductivity , quantum mechanics , nambu–jona lasinio model , quark
De gustibus: β‐homoDNA has the singular property of being able to pair with homochiral complements of opposite chirality, with a greater stability than that observed in the corresponding isochiral complexes. Relevant to etiological investigations on nucleic acid structure, these results suggest the existence of a relationship between carbohydrate structure and stereoselectivity of the hybridization processes of the corresponding nucleic acids.