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Cover Picture: Protection and Deprotection of DNA—High‐Temperature Stability of Nucleic Acid Barcodes for Polymer Labeling (Angew. Chem. Int. Ed. 15/2013)
Author(s) -
Paunescu Daniela,
Fuhrer Roland,
Grass Robert N.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301653
Subject(s) - polymer , dna , nucleic acid , chemistry , bottle , materials science , chemical engineering , biochemistry , organic chemistry , composite material , engineering
When DNA is encapsulated in a silica sphere, the encoded information can be protected for storage and distribution, much in the way a bottle protects the message inside from the rough sea. As R. N. Grass et al. describe in their Communication on page 4269 ff. , a silica layer only 10 nm thick is sufficient to protect DNA from high temperatures and aggressive radical conditions. The glass can be broken by reaction with HF and the information recovered for biochemical analysis.