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Covalent Small‐Molecule–RNA Complex Formation Enables Cellular Profiling of Small‐Molecule–RNA Interactions
Author(s) -
Guan Lirui,
Disney Matthew D.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301639
Subject(s) - rna , small molecule , chemistry , molecule , profiling (computer programming) , computational biology , microbiology and biotechnology , covalent bond , biophysics , biology , biochemistry , computer science , gene , organic chemistry , operating system
Won't let you go! A strategy is described to design small molecules that react with their cellular RNA targets. This approach not only improves the activity of compounds targeting RNA in cell culture by a factor of about 2500 but also enables cell‐wide profiling of its RNA targets.