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Plague Detection by Anti‐carbohydrate Antibodies
Author(s) -
Anish Chakkumkal,
Guo Xiaoqiang,
Wahlbrink Annette,
Seeberger Peter H.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301633
Subject(s) - plague (disease) , virology , antibody , biology , geography , immunology , archaeology
The sugar coat of “Black Death” betrays it. The plague can be detected by monoclonal anti‐carbohydrate antibodies. In a new technique, a plague‐specific oligosaccharide antigen (see structure) is synthesized. With the help of lipopolysaccharide (LPS)‐specific monoclonal antibodies (mAbs), the presence of the plague pathogen Yersinia pestis can then be detected in serum from patients by using a glycan microarray.