Top‐Down Chemoenzymatic Approach to a High‐Mannose‐Type Glycan Library: Synthesis of a Common Precursor and Its Enzymatic Trimming | Zendy

Koizumi Akihiko | Zendy; Matsuo Ichiro | Zendy; Takatani Maki | Zendy; Seko Akira | Zendy; Hachisu Masakazu | Zendy; Takeda Yoichi | Zendy; Ito Yukishige | Zendy

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Top‐Down Chemoenzymatic Approach to a High‐Mannose‐Type Glycan Library: Synthesis of a Common Precursor and Its Enzymatic Trimming

Author(s) -

Koizumi Akihiko,

Matsuo Ichiro,

Takatani Maki,

Seko Akira,

Hachisu Masakazu,

Takeda Yoichi,

Ito Yukishige

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201301613

Subject(s) - trimming , mannose , glycan , enzyme , chemistry , combinatorial chemistry , biochemistry , computer science , glycoprotein , programming language

From the stacks : A novel method for construction of a high‐mannose‐type glycan library by systematic enzymatic trimming of a single synthetic Man 9 ‐based precursor was developed. Efficient chemical synthesis of the tetradecasaccharide common precursor and orthogonal enzymatic trimming to obtain all M 8‐9 and G 1 M 8‐9 derivatives was demonstrated. G=glucose, M=mannose.

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