Premium
Optimizing P,N‐Bidentate Ligands for Oxidative Gold Catalysis: Efficient Intermolecular Trapping of α‐Oxo Gold Carbenes by Carboxylic Acids
Author(s) -
Ji Kegong,
Zhao Yulong,
Zhang Liming
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301601
Subject(s) - denticity , intermolecular force , chemistry , catalysis , trapping , oxidative addition , oxidative phosphorylation , combinatorial chemistry , photochemistry , organic chemistry , metal , molecule , ecology , biology , biochemistry
Control confirmed : Optimization of P,N‐bidentate ligands ( L ) reveals the importance of conformation control for intermolecular trapping of reactive α‐oxo gold carbene intermediates. As a result, the highly efficient and broadly applicable synthesis of carboxymethyl ketones from readily available carboxylic acids and terminal alkynes proceeds under mild reaction conditions.