Distinct Conformational States of the Alzheimer β‐Amyloid Peptide Can Be Detected by High‐Pressure NMR Spectroscopy

Folding under pressure : High‐pressure NMR spectroscopy detects three different conformational states of the Aβ‐peptide in solution: a compactly folded state 1 , a partially folded state 2′ , and a random‐coil like state 2′′ (see plot, p=population). At ambient pressure the folded state 1 dominates which probably has a high affinity to fibrils and thus may promote fibril formation.