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Back Cover: Supramolecular Control of Selectivity in Hydroformylation of Vinyl Arenes: Easy Access to Valuable β‐Aldehyde Intermediates (Angew. Chem. Int. Ed. 14/2013)
Author(s) -
Dydio Paweł,
Reek Joost N. H.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301447
Subject(s) - hydroformylation , selectivity , supramolecular chemistry , aldehyde , catalysis , chemistry , supramolecular catalysis , combinatorial chemistry , ligand (biochemistry) , cover (algebra) , substrate (aquarium) , organic chemistry , rhodium , molecule , mechanical engineering , biochemistry , receptor , oceanography , engineering , geology
Precise selectivity control in transition‐metal catalysis is critical for modern chemical synthesis. In their Communication on page 3878 ff. , J. N. H. Reek and P. Dydio demonstrate that substrate preorganization through noncovalent supramolecular interactions with the ligand is a powerful enabling strategy to control selectivity, and gives access to usually unfavored products. As exemplified for the Rh‐catalyzed hydroformylation of vinyl arenes, this approach opens up new avenues in the synthesis of valuable compounds.