Highly Enantioselective Construction of 3‐Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl α‐Fluorinated  gem ‐Diols to  N ‐Benzyl Isatins | Zendy

Saidalimu Ibrayim | Zendy; Fang Xiang | Zendy; He XiaoPeng | Zendy; Liang Jing | Zendy; Yang Xueyan | Zendy; Wu Fanhong | Zendy

Premium

Highly Enantioselective Construction of 3‐Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl α‐Fluorinated gem ‐Diols to N ‐Benzyl Isatins

Author(s) -

Saidalimu Ibrayim,

Fang Xiang,

He XiaoPeng,

Liang Jing,

Yang Xueyan,

Wu Fanhong

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201301443

Subject(s) - aldol reaction , enantioselective synthesis , chemistry , trifluoromethyl , cleavage (geology) , organic chemistry , bond cleavage , medicinal chemistry , catalysis , materials science , alkyl , fracture (geology) , composite material

An organocatalytic asymmetric direct aldol addition reaction that involves cleavage of a carbon–carbon bond through the release of trifluoroacetate was developed. The protocol is wide in scope, generating the desired oxindoles of biological interest in nearly quantitative yields (up to 99 %) with excellent enantioselectivities (up to 98 % ee ) and diastereoselectivities (up to 99:1 d.r.).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research