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Synthesis of Paclitaxel‐Conjugated β‐Cyclodextrin Polyrotaxane and Its Antitumor Activity
Author(s) -
Yu Shuling,
Zhang Yajun,
Wang Xin,
Zhen Xu,
Zhang Zhaoheng,
Wu Wei,
Jiang Xiqun
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301397
Subject(s) - conjugated system , paclitaxel , cyclodextrin , drug delivery , chemistry , tumor cells , computer science , cancer research , chemotherapy , medicine , organic chemistry , polymer , surgery
Cap it all : A β‐cyclodextrin polyrotaxane was synthesized by using poly(propylene glycol) as the axle and β‐cyclodextrin as the end cap. An antitumor agent, paclitaxel, was conjugated to it. The drug‐conjugated polyrotaxane penetrates deep into tumors, impedes tumor growth, and prolongs the life of tumor‐bearing mice better than Taxol.