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Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid‐State 19 F NMR Spectroscopy
Author(s) -
Tkachenko Anton N.,
Radchenko Dmytro S.,
Mykhailiuk Pavel K.,
Afonin Sergii,
Ulrich Anne S.,
Komarov Igor V.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301344
Subject(s) - magainin , phenylalanine , chemistry , nuclear magnetic resonance spectroscopy , solid state , peptide , spectroscopy , fluorine 19 nmr , membrane , solid state nuclear magnetic resonance , amino acid , peptide synthesis , stereochemistry , combinatorial chemistry , nuclear magnetic resonance , biochemistry , antimicrobial peptides , physics , quantum mechanics
Designer label : A novel α‐amino acid was designed as a conformationally restricted analogue of phenylalanine. It was synthesized and incorporated into the representative membrane‐active peptide Magainin 2, to demonstrate its suitablility for structure analysis in oriented membranes by solid‐state 19 F NMR spectroscopy.