Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid‐State  19 F NMR Spectroscopy | Zendy

Tkachenko Anton N. | Zendy; Radchenko Dmytro S. | Zendy; Mykhailiuk Pavel K. | Zendy; Afonin Sergii | Zendy; Ulrich Anne S. | Zendy; Komarov Igor V. | Zendy

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Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid‐State 19 F NMR Spectroscopy

Author(s) -

Tkachenko Anton N.,

Radchenko Dmytro S.,

Mykhailiuk Pavel K.,

Afonin Sergii,

Ulrich Anne S.,

Komarov Igor V.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201301344

Subject(s) - magainin , phenylalanine , chemistry , nuclear magnetic resonance spectroscopy , solid state , peptide , spectroscopy , fluorine 19 nmr , membrane , solid state nuclear magnetic resonance , amino acid , peptide synthesis , stereochemistry , combinatorial chemistry , nuclear magnetic resonance , biochemistry , antimicrobial peptides , physics , quantum mechanics

Designer label : A novel α‐amino acid was designed as a conformationally restricted analogue of phenylalanine. It was synthesized and incorporated into the representative membrane‐active peptide Magainin 2, to demonstrate its suitablility for structure analysis in oriented membranes by solid‐state 19 F NMR spectroscopy.

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