Premium
Rhodium‐Catalyzed ortho Acylation of Aromatic Carboxylic Acids
Author(s) -
Mamone Patrizia,
Danoun Grégory,
Gooßen Lukas J.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301328
Subject(s) - acylation , rhodium , carboxylic acid , friedel–crafts reaction , chemistry , catalysis , benzoic acid , organic chemistry , ketone , aryl , combinatorial chemistry , alkyl
New directions : The carboxylic acid functional group directs the ortho acylation of benzoic acids with carboxylic anhydrides in the presence of a rhodium catalyst (see scheme; cod=cyclo‐1,5‐octadiene). The acylation at the ortho position is complementary to the meta selectivity of Friedel–Crafts reactions. The resulting products can undergo protodecarboxylation to deliver an aryl ketone.