Rhodium‐Catalyzed  ortho  Acylation of Aromatic Carboxylic Acids | Zendy

Mamone Patrizia | Zendy; Danoun Grégory | Zendy; Gooßen Lukas J. | Zendy

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Rhodium‐Catalyzed ortho Acylation of Aromatic Carboxylic Acids

Author(s) -

Mamone Patrizia,

Danoun Grégory,

Gooßen Lukas J.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201301328

Subject(s) - acylation , rhodium , carboxylic acid , friedel–crafts reaction , chemistry , catalysis , benzoic acid , organic chemistry , ketone , aryl , combinatorial chemistry , alkyl

New directions : The carboxylic acid functional group directs the ortho acylation of benzoic acids with carboxylic anhydrides in the presence of a rhodium catalyst (see scheme; cod=cyclo‐1,5‐octadiene). The acylation at the ortho position is complementary to the meta selectivity of Friedel–Crafts reactions. The resulting products can undergo protodecarboxylation to deliver an aryl ketone.

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