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Enantioselective N‐Heterocyclic Carbene Catalyzed Aza‐Benzoin Reaction of Enals with Activated Ketimines
Author(s) -
Sun LiHui,
Liang ZhiQin,
Jia WenQiang,
Ye Song
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301304
Subject(s) - enantioselective synthesis , carbene , benzoin , catalysis , chemistry , computer science , combinatorial chemistry , organic chemistry
α‐Amino ketones , which are versatile building blocks for organic synthesis, were obtained with the title reaction. A free hydroxy group on the NHC catalyst was found to be crucial for the reaction, and the possible competing reaction through a homoenolate or enolate was not observed with this catalyst (see scheme).
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