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The Electrophilic α‐Amination of α‐Alkyl‐β‐Ketoesters with In Situ Generated Nitrosoformates
Author(s) -
Selig Philipp
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301282
Subject(s) - electrophilic amination , amination , electrophile , reagent , chemistry , alkyl , catalysis , in situ , combinatorial chemistry , lewis acids and bases , organic chemistry
Lewis acid and oxidation catalysis are merged in the reaction discussed here, which provides access to diversely substituted N ‐hydroxycarbamates (see scheme). This reaction highlights the potential of nitrosoformates as electrophilic amination reagents as well as the benefits of aerobic oxidation for the formation of highly reactive species.