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Cover Picture: Bio‐Inspired Catalytic Imine Reduction by Rhodium Complexes with Tethered Hantzsch Pyridinium Groups: Evidence for Direct Hydride Transfer from Dihydropyridine to Metal‐Activated Substrate (Angew. Chem. Int. Ed. 12/2013)
Author(s) -
McSkimming Alex,
Bhadbhade Mohan M.,
Colbran Stephen B.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301157
Subject(s) - chemistry , transfer hydrogenation , catalysis , rhodium , imine , pyridine , hydride , ruthenium , combinatorial chemistry , stereochemistry , metal , medicinal chemistry , organic chemistry
Catalysis in a teacup, inspired by nature Alfred Werner (left) received the 1913 Nobel Prize for his coordination theory of transition metal compounds, and Arthur Hantzsch (right) discovered the route to (dihydro)pyridines that bear his name. In their Communication on page 3411 ff., S. B. Colbran et al. disclose that conjugation of rhodium and Hantzsch pyridine centers affords a catalyst for the transfer hydrogenation of imines in air under ambient conditions. A key step in the catalysis mimics that in metallo‐(de)hydrogenase enzymes.