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Multi‐Chromatic pH‐Activatable 19 F‐MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical‐Shift Barcodes
Author(s) -
Huang Xiaonan,
Huang Gang,
Zhang Shanrong,
Sagiyama Koji,
Togao Osamu,
Ma Xinpeng,
Wang Yiguang,
Li Yang,
Soesbe Todd C.,
Sumer Baran D.,
Takahashi Masaya,
Sherry A. Dean,
Gao Jinming
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301135
Subject(s) - computer science , micelle , binary number , content delivery , polymer , nanotechnology , chemistry , materials science , mathematics , organic chemistry , computer network , aqueous solution , arithmetic
Imaging all the people : Using ionizable diblock copolymers a series of nanoprobes encoded with different 19 F reporters for specific pH transitions is prepared for use in MRI. The pH response of the nanoprobes is extremely sharp (ΔpH ON/OFF ≈0.25 pH), and results from the disassembly of polymer micelles (see scheme). A collection of three nanoprobes provides the proof of concept and allows for a qualitative measurement of environmental pH values.