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Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation of 1‐Aryl‐Substituted Dihydroisoquinolines: Access to Valuable Chiral 1‐Aryl‐Tetrahydroisoquinoline Scaffolds
Author(s) -
Wu Zi,
Perez Marc,
Scalone Michelangelo,
Ayad Tahar,
RatovelomananaVidal Virginie
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301134
Subject(s) - transfer hydrogenation , aryl , enantioselective synthesis , ruthenium , catalysis , combinatorial chemistry , tetrahydroisoquinoline , chemistry , organic chemistry , computer science , alkyl
Give me an H! Give me another H! The first general and highly enantioselective Ru‐catalyzed transfer hydrogenation of a wide range of 1‐aryl‐substituted 1,2,3,4‐dihydroisoquinolines is described. This atom‐economic reaction proceeds under mild conditions, allowing rapid access to the corresponding biologically relevant 1‐aryl‐tetrahydroisoquinoline derivatives, in high yields and enantioselectivities of up to 99 %.