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BODIPY–Tetrazine Derivatives as Superbright Bioorthogonal Turn‐on Probes
Author(s) -
Carlson Jonathan C. T.,
Meimetis Labros G.,
Hilderbrand Scott A.,
Weissleder Ralph
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301100
Subject(s) - tetrazine , bioorthogonal chemistry , fluorophore , bodipy , computer science , quenching (fluorescence) , förster resonance energy transfer , chemistry , fluorescence , information retrieval , combinatorial chemistry , physics , organic chemistry , click chemistry , quantum mechanics
The fastest and the brightest : A new design that intimately connects tetrazine to a BODIPY fluorophore enables exceptionally efficient energy transfer and quenching. Upon reaction of the tetrazine, the brightness of the fluorophore increases more than a thousand‐fold, which is a fluorogenic activation up to two orders of magnitude greater than previously described.