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Manganese‐Catalyzed Oxidative Benzylic C–H Fluorination by Fluoride Ions
Author(s) -
Liu Wei,
Groves John T.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301097
Subject(s) - manganese , fluoride , triethylamine , catalysis , fluorine , nucleophile , chemistry , combinatorial chemistry , ion , computer science , medicinal chemistry , organic chemistry , inorganic chemistry
An efficient protocol for the selective fluorination of benzylic CH bonds is described. The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources, such as triethylamine trihydrofluoride and KF. Reaction rates are sufficiently high (30 min) to allow adoption for the incorporation of 18 F fluoride sources for PET imaging applications.
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