Premium
Unveiling Latent α‐Iminocarbene Reactivity for Intermolecular Cascade Reactions through Alkyne Oxidative Amination
Author(s) -
Mace Nina,
Thornton Aaron R.,
Blakey Simon B.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301087
Subject(s) - alkyne , intermolecular force , reactivity (psychology) , cascade , amination , chemistry , variety (cybernetics) , computer science , combinatorial chemistry , database , organic chemistry , molecule , catalysis , artificial intelligence , medicine , alternative medicine , pathology , chromatography
Setting a trap : Described is the development of a metallonitrene‐initiated alkyne oxidation cascade with intermolecular trapping of the reactive intermediate with a variety of allyl ethers to provide α‐oxyimine products in which new CN, CO, and CC bonds have all been generated (see Scheme; tfacam=trifluoroacetamide).