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Premium Gold‐Catalyzed Cyclizations of cis ‐Enediynes: Insights into the Nature of Gold–Aryne Interactions
Wang Youliang,
Yepremyan Akop,
Ghorai Subir,
Todd Robert,
Aue Donald H.,
Zhang Liming
Publication year2013
Publication title
angewandte chemie international edition
Resource typeJournals
PublisherWILEY‐VCH Verlag
Golden aryne? Gold aryne complexes are inferred as transition states in dual gold‐catalyzed cyclizations of cis ‐enediynes (see scheme; DCE=1,2‐dichloroethane). They are better described as ortho ‐aurophenyl cations, which react with weak nucleophiles and undergo facile intramolecular insertions into C(sp 3 )H bonds. Indanes, fused heteroarenes, and phenol derivatives are readily prepared using this method.
Subject(s)aryne , catalysis , chemistry , combinatorial chemistry , computational chemistry , intramolecular force , medicinal chemistry , nucleophile , organic chemistry , stereochemistry
SCImago Journal Rank5.831

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