Cu‐Catalyzed Chemoselective Preparation of 2‐(Pinacolato)boron‐Substituted Allylcopper Complexes and their In Situ Site‐, Diastereo‐, and Enantioselective Additions to Aldehydes and Ketones | Zendy

Meng Fanke | Zendy; Jang Hwanjong | Zendy; Jung Byunghyuck | Zendy; Hoveyda Amir H. | Zendy

Premium

Cu‐Catalyzed Chemoselective Preparation of 2‐(Pinacolato)boron‐Substituted Allylcopper Complexes and their In Situ Site‐, Diastereo‐, and Enantioselective Additions to Aldehydes and Ketones

Author(s) -

Meng Fanke,

Jang Hwanjong,

Jung Byunghyuck,

Hoveyda Amir H.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201301018

Subject(s) - enantioselective synthesis , catalysis , boron , chemistry , combinatorial chemistry , component (thermodynamics) , computer science , organic chemistry , physics , thermodynamics

Sustainable, efficient, selective : A three‐component, single‐vessel Cu‐catalyzed method for chemo‐, diastereo‐, and enantioselective conversion of B 2 (pin) 2 , monosubstituted allenes, and aldehydes or ketones to 2‐B(pin)‐substituted homoallylic alkoxides is described. Subsequent functionalization delivers valuable products in up to >98:2 d.r. and 97:3 e.r. (see scheme).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research