Premium
Direct Deamination of Primary Amines by Water To Produce Alcohols
Author(s) -
Khusnutdinova Julia R.,
BenDavid Yehoshoa,
Milstein David
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201301000
Subject(s) - deamination , primary (astronomy) , reagent , chemistry , combinatorial chemistry , pyrrolidine , aniline , transformation (genetics) , computer science , world wide web , organic chemistry , biochemistry , physics , astronomy , gene , enzyme
Just add water! The title reaction is catalyzed by an acridine‐based pincer complex ( 1 , see scheme). This one‐step transformation uses water as the only reagent in the absence of additional bases, oxidants, or reductants. Cyclization of 1,4‐diaminobutane and 1,6‐diaminohexane catalyzed by 1 leads to the formation of pyrrolidine and azepane, respectively.