Direct Deamination of Primary Amines by Water To Produce Alcohols | Zendy

Khusnutdinova Julia R. | Zendy; BenDavid Yehoshoa | Zendy; Milstein David | Zendy

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Direct Deamination of Primary Amines by Water To Produce Alcohols

Author(s) -

Khusnutdinova Julia R.,

BenDavid Yehoshoa,

Milstein David

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201301000

Subject(s) - deamination , primary (astronomy) , reagent , chemistry , combinatorial chemistry , pyrrolidine , aniline , transformation (genetics) , computer science , world wide web , organic chemistry , biochemistry , physics , astronomy , gene , enzyme

Just add water! The title reaction is catalyzed by an acridine‐based pincer complex ( 1 , see scheme). This one‐step transformation uses water as the only reagent in the absence of additional bases, oxidants, or reductants. Cyclization of 1,4‐diaminobutane and 1,6‐diaminohexane catalyzed by 1 leads to the formation of pyrrolidine and azepane, respectively.

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