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Synthesis and Application of β‐Substituted Pauson–Khand Adducts: Trifluoromethyl as a Removable Steering Group
Author(s) -
Aiguabella Nuria,
del Pozo Carlos,
Verdaguer Xavier,
Fustero Santos,
Riera Antoni
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300907
Subject(s) - trifluoromethyl , regioselectivity , intermolecular force , chemistry , adduct , alkyne , structural isomer , group (periodic table) , stereochemistry , medicinal chemistry , organic chemistry , molecule , catalysis , alkyl
Against the rules : The synthesis of the previously unknown β‐substituted regioisomers of the intermolecular Pauson–Khand reaction of terminal alkynes is reported. This regiochemistry was achieved by using the trifluoromethyl group as a removable directing group on the alkyne.