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Rhodium(III)‐Catalyzed Redox‐Neutral Coupling of N ‐Phenoxyacetamides and Alkynes with Tunable Selectivity
Author(s) -
Liu Guixia,
Shen Yangyang,
Zhou Zhi,
Lu Xiyan
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300881
Subject(s) - rhodium , oxidizing agent , selectivity , catalysis , combinatorial chemistry , chemistry , coupling (piping) , surface modification , medicinal chemistry , computer science , database , organic chemistry , materials science , metallurgy
Give it a tweak : A novel oxidizing directing group was developed for a rhodium(III)‐catalyzed CH functionalization of N ‐phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho ‐hydroxyphenyl‐substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp*=C 5 Me 5 ).