Rhodium(III)‐Catalyzed Redox‐Neutral Coupling of  N ‐Phenoxyacetamides and Alkynes with Tunable Selectivity | Zendy

Liu Guixia | Zendy; Shen Yangyang | Zendy; Zhou Zhi | Zendy; Lu Xiyan | Zendy

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Rhodium(III)‐Catalyzed Redox‐Neutral Coupling of N ‐Phenoxyacetamides and Alkynes with Tunable Selectivity

Author(s) -

Liu Guixia,

Shen Yangyang,

Zhou Zhi,

Lu Xiyan

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201300881

Subject(s) - rhodium , oxidizing agent , selectivity , catalysis , combinatorial chemistry , chemistry , coupling (piping) , surface modification , medicinal chemistry , computer science , database , organic chemistry , materials science , metallurgy

Give it a tweak : A novel oxidizing directing group was developed for a rhodium(III)‐catalyzed CH functionalization of N ‐phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho ‐hydroxyphenyl‐substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp*=C 5 Me 5 ).

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