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Identification of Cystathionine β‐Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe
Author(s) -
Thorson Megan K.,
Majtan Tomas,
Kraus Jan P.,
Barrios Amy M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300841
Subject(s) - cystathionine beta synthase , hydrogen sulfide , chemistry , atp synthase , biochemistry , enzyme , hydrogen sulphide , cystathionine gamma lyase , cysteine , organic chemistry , sulfur
Buzzing with activity : A hydrogen sulfide selective fluorogenic probe, 7‐azido‐4‐methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β‐synthase activity, and is suitable for the high‐throughput discovery of novel enzyme inhibitors.