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A Three‐Component Palladium‐Catalyzed Oxidative CC Coupling Reaction: A Domino Process in Two Dimensions
Author(s) -
Nimje Roshan Y.,
Leskinen Mikko V.,
Pihko Petri M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300833
Subject(s) - domino , component (thermodynamics) , palladium , catalysis , process (computing) , computer science , oxidative phosphorylation , chemistry , coupling (piping) , combinatorial chemistry , service (business) , domino effect , process engineering , organic chemistry , materials science , business , engineering , physics , programming language , thermodynamics , biochemistry , metallurgy , marketing , nuclear physics
Easy as ABC… or CBA! Indoles can be selectively functionalized twice by a catalytic oxidative three‐component coupling of arylboronates and β‐ketoesters. The difference in the rates (see scheme) of the competing processes are amplified under the conditions of the three‐component reaction.