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Red‐Light‐Controlled Protein–RNA Crosslinking with a Genetically Encoded Furan
Author(s) -
Schmidt Moritz J.,
Summerer Daniel
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300754
Subject(s) - rna , peptide , computational biology , chemistry , biology , biochemistry , microbiology and biotechnology , gene
Well red : A protein‐RNA crosslinker has been genetically encoded that can be controlled with red light (see scheme), thus offering high penetration depths in biological materials. This should enable the discovery and mapping of transient protein–RNA interactions and enable the design of peptide‐ and protein‐based drugs for RNA‐targeted photodynamic therapy.