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Reduction of Quinones by NADH Catalyzed by Organoiridium Complexes
Author(s) -
Liu Zhe,
Deeth Robert J.,
Butler Jennifer S.,
Habtemariam Abraha,
Newton Mark E.,
Sadler Peter J.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300747
Subject(s) - chemistry , electron transfer , hydride , catalysis , redox , photochemistry , cyclopentadienyl complex , cofactor , electron transport chain , oxidation state , oxidation reduction , metal , stereochemistry , medicinal chemistry , inorganic chemistry , organic chemistry , enzyme , biochemistry
One electron at a time : Half‐sandwich organometallic cyclopentadienyl–Ir III complexes containing N,N‐chelated ligands can catalyze the reduction of quinones (Q), such as vitamin K 3 , to semiquinones (Q .− ) by coenzyme NADH (see picture). DFT calculations suggest that the mechanism involves hydride transfer followed by two one‐electron transfers and the unusual Ir II oxidation state as a key transient intermediate.
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