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Synthesis of Epoxyisoprostanes: Effects in Reducing Secretion of Pro‐inflammatory Cytokines IL‐6 and IL‐12
Author(s) -
Egger Julian,
Bretscher Peter,
Freigang Stefan,
Kopf Manfred,
Carreira Erick M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300739
Subject(s) - secretion , computer science , order (exchange) , world wide web , computational biology , chemistry , biochemistry , biology , business , finance
Anti‐inflammatory : The efficient and general synthetic route to the elusive epoxyisoprostanoid phospholipids PECPC and PEIPC, along with the isoprostanoids EC and EI, relies on a number of stereo‐ and chemoselective steps, including a CH insertion for the rapid construction of the cyclopentanone ring. The synthesized compounds display unprecedented biological activity in reducing the secretion of pro‐inflammatory cytokines.