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Thermo‐Responsive Hydrogel Layers Imprinted with RGDS Peptide: A System for Harvesting Cell Sheets
Author(s) -
Pan Guoqing,
Guo Qianping,
Ma Yue,
Yang Huilin,
Li Bin
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300733
Subject(s) - imprinting (psychology) , nanotechnology , molecular imprinting , adhesive , peptide , computer science , materials science , world wide web , chemistry , biochemistry , gene , layer (electronics) , selectivity , catalysis
The efficient promotion of cell adhesion on a polymer surface and detachment of sheets of cells is possible with thermo‐responsive cell culture substrates that are biofunctionalized through noncovalent molecular imprinting. The key is the thermo‐responsive “specific binding” of the cell‐adhesive peptide RGDS on the cell sheet harvest system (see picture).