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Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials
Author(s) -
Sehl Torsten,
Hailes Helen C.,
Ward John M.,
Wardenga Rainer,
von Lieres Eric,
Offermann Heike,
Westphal Robert,
Pohl Martina,
Rother Dörte
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300718
Subject(s) - diastereomer , cascade , pseudoephedrine , ephedrine , substrate (aquarium) , product (mathematics) , chemistry , computer science , cascade reaction , combinatorial chemistry , information retrieval , database , stereochemistry , organic chemistry , mathematics , chromatography , catalysis , psychology , biology , geometry , neuroscience , ecology
Two steps in one pot : An enzyme cascade consisting of a lyase and an ( R )‐ or ( S )‐selective ω‐transaminase (TA) provides (1 R ,2 R )‐norpseudoephedrine and (1 R ,2 S )‐norephedrine in only two steps. The intermediate is not isolated in this one‐pot reaction and the products are obtained in high enantio‐ and diastereomeric purity. Moreover, the by‐product from the second reaction can be recycled to serve as the substrate for the first reaction.