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Platinum(IV) Prodrugs with Haloacetato Ligands in the Axial Positions can Undergo Hydrolysis under Biologically Relevant Conditions
Author(s) -
Wexselblatt Ezequiel,
Yavin Eylon,
Gibson Dan
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300640
Subject(s) - prodrug , hydrolysis , chemistry , platinum , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , catalysis
Losing ligands rapidly : Pt IV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH 7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H 2 18 O and ESI‐MS analysis.
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