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Methylene‐Bridged Bis(imidazoline)‐Derived 2‐Oxopyrimidinium Salts as Catalysts for Asymmetric Michael Reactions
Author(s) -
Sheshenev Andrey E.,
Boltukhina Ekaterina V.,
White Andrew J. P.,
Hii King Kuok Mimi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300614
Subject(s) - chemistry , michael reaction , catalysis , imine , nucleophile , methyl vinyl ketone , organic chemistry , stereocenter , medicinal chemistry , enantioselective synthesis
In nothing flat : The title salts, having planar nitrogen centers, were utilized successfully as phase‐transfer catalysts for asymmetric Michael reactions of tert ‐butyl glycinate benzophenone Schiff base with vinyl ketone and chalcone derivatives, thus providing excellent levels of diastereo‐ and enantiocontrol (see scheme).