Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β‐Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes | Zendy

Srimani Dipankar | Zendy; BenDavid Yehoshoa | Zendy; Milstein David | Zendy

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Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β‐Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes

Author(s) -

Srimani Dipankar,

BenDavid Yehoshoa,

Milstein David

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201300574

Subject(s) - pincer movement , ruthenium , catalysis , chemistry , combinatorial chemistry , organic chemistry , database , computer science

Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective CN and CC bond formation. This atom‐economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.

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