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Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β‐Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes
Author(s) -
Srimani Dipankar,
BenDavid Yehoshoa,
Milstein David
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300574
Subject(s) - pincer movement , ruthenium , catalysis , chemistry , combinatorial chemistry , organic chemistry , database , computer science
Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective CN and CC bond formation. This atom‐economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.