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A Palladium/Chiral Amine Co‐catalyzed Enantioselective Dynamic Cascade Reaction: Synthesis of Polysubstituted Carbocycles with a Quaternary Carbon Stereocenter
Author(s) -
Ma Guangning,
Afewerki Samson,
Deiana Luca,
PaloNieto Carlos,
Liu Leifeng,
Sun Junliang,
Ibrahem Ismail,
Córdova Armando
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300559
Subject(s) - stereocenter , enantioselective synthesis , palladium , amine gas treating , catalysis , quaternary carbon , chemistry , organic chemistry , combinatorial chemistry , cascade reaction
Polysubstituted 5‐ and 6‐membered carbocycles were synthesized by the title reaction. The one‐pot dynamic relay process generates four new stereocenters, including a quaternary carbon center, in a highly enantioselective fashion (99.5:0.5→99:0.5 e.r.) by using a simple combination of palladium and chiral amine co‐catalysts.