A Palladium/Chiral Amine Co‐catalyzed Enantioselective Dynamic Cascade Reaction: Synthesis of Polysubstituted Carbocycles with a Quaternary Carbon Stereocenter | Zendy

Ma Guangning | Zendy; Afewerki Samson | Zendy; Deiana Luca | Zendy; PaloNieto Carlos | Zendy; Liu Leifeng | Zendy; Sun Junliang | Zendy; Ibrahem Ismail | Zendy; Córdova Armando | Zendy

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A Palladium/Chiral Amine Co‐catalyzed Enantioselective Dynamic Cascade Reaction: Synthesis of Polysubstituted Carbocycles with a Quaternary Carbon Stereocenter

Author(s) -

Ma Guangning,

Afewerki Samson,

Deiana Luca,

PaloNieto Carlos,

Liu Leifeng,

Sun Junliang,

Ibrahem Ismail,

Córdova Armando

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201300559

Subject(s) - stereocenter , enantioselective synthesis , palladium , amine gas treating , catalysis , quaternary carbon , chemistry , organic chemistry , combinatorial chemistry , cascade reaction

Polysubstituted 5‐ and 6‐membered carbocycles were synthesized by the title reaction. The one‐pot dynamic relay process generates four new stereocenters, including a quaternary carbon center, in a highly enantioselective fashion (99.5:0.5→99:0.5 e.r.) by using a simple combination of palladium and chiral amine co‐catalysts.

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