Selenomethylene Locked Nucleic Acid Enables Reversible Hybridization in Response to Redox Changes | Zendy

Morihiro Kunihiko | Zendy; Kodama Tetsuya | Zendy; Moai Yoshihiro | Zendy; Veedu Rakesh N. | Zendy; Obika Satoshi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Selenomethylene Locked Nucleic Acid Enables Reversible Hybridization in Response to Redox Changes

Author(s) -

Morihiro Kunihiko,

Kodama Tetsuya,

Moai Yoshihiro,

Veedu Rakesh N.,

Obika Satoshi

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201300555

Subject(s) - nucleic acid , molecular beacon , oligonucleotide , fluorophore , redox , chemistry , computer science , nanotechnology , combinatorial chemistry , computational biology , biophysics , fluorescence , biochemistry , materials science , physics , biology , dna , organic chemistry , quantum mechanics

Locking up selenium : A new conformationally restricted nucleic acid with a 2′,4′‐selenomethylene bridge (SeLNA) can be reversibly converted into its oxidized form (SeOLNA), and the hybridization of a modified oligonucleotide was shown to be dependent on the oxidation state. A SeLNA‐modified molecular‐beacon‐type probe (see scheme; F=fluorophore, Q=quencher) can be used as a sensor for changes in the redox environment.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research