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A Genetically Encoded 19 F NMR Probe for Tyrosine Phosphorylation
Author(s) -
Li Fahui,
Shi Pan,
Li Jiasong,
Yang Fan,
Wang Tianyuan,
Zhang Wei,
Gao Feng,
Ding Wei,
Li Dong,
Li Juan,
Xiong Ying,
Sun Jinpeng,
Gong Weimin,
Tian Changlin,
Wang Jiangyun
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300463
Subject(s) - phosphorylation , tyrosine , tyrosine phosphorylation , chemistry , computational biology , service (business) , computer science , biochemistry , information retrieval , biology , economy , economics
Simple and selective : Tyrosine phosphorylation is a pivotal post‐translational modification which regulates the enzymatic activity, protein conformation, and protein–protein interactions. The highly efficient genetic incorporation of 3,5‐difluorotyrosine (F2Y) in E. coli and the use of F2Y as a 19 F NMR probe for the tyrosine phosphorylation are reported (see picture).
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