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Inside Cover: Two‐Way Nanopore Sensing of Sequence‐Specific Oligonucleotides and Small‐Molecule Targets in Complex Matrices Using Integrated DNA Supersandwich Structures (Angew. Chem. Int. Ed. 7/2013)
Author(s) -
Liu Nannan,
Jiang Yanan,
Zhou Yahong,
Xia Fan,
Guo Wei,
Jiang Lei
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201300426
Subject(s) - nanodevice , nanopore , oligonucleotide , cover (algebra) , dna , nanotechnology , nanopore sequencing , molecule , sequence (biology) , materials science , chemistry , biophysics , dna sequencing , biology , engineering , biochemistry , mechanical engineering , organic chemistry
DNA supersandwich structures work as gatekeepers for solid‐state nanopores as part of a target‐specific nanofluidic sensor for both oligonucleotides and small molecules, as shown by F. Xia, W. Guo et al. in their Communication on page 2007 ff. The DNA superstructures enhance the sensitivity and reduce the background signal, so that the biohybrid nanodevice also works well in complex mixtures, such as mammalian serum.